Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release.

نویسندگان

  • Bárbara Herranz-Blanco
  • Laura R Arriaga
  • Ermei Mäkilä
  • Alexandra Correia
  • Neha Shrestha
  • Sabiruddin Mirza
  • David A Weitz
  • Jarno Salonen
  • Jouni Hirvonen
  • Hélder A Santos
چکیده

A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.

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عنوان ژورنال:
  • Lab on a chip

دوره 14 6  شماره 

صفحات  -

تاریخ انتشار 2014